Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.66 |
| ▸ | HTR1A | P08908 | 7/20 | 0.66 |
| ▸ | DRD4 | P21917 | 6/20 | 0.66 |
| ▸ | HTR2A | P28223 | 5/20 | 0.66 |
| ▸ | DRD3 | P35462 | 5/20 | 0.66 |
| ▸ | HRH1 | P35367 | 3/20 | 0.66 |
| ▸ | HTR2C | P28335 | 2/20 | 0.66 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | DRD1 | P21728 | 2/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114078 | 0.91 | HTR1A (0.72) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL3197900 | 0.88 | HTR1A (0.66) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL8045431 | 0.86 | KCNH2 (0.69) | DRD2HTR1AHTR2ADRD3HRH1 | |
| SCHEMBL11832182 | 0.85 | DRD2 (0.88) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL7126140 | 0.85 | GFER (0.53) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL19107617 | 0.85 | MAPT (0.58) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL12041413 | 0.84 | DRD2 (0.61) | DRD2HTR1ADRD4HTR2ADRD3 | |
| Maleic Acid SCHEMBL30604712 | 0.84 | HTR1A (0.58) | DRD2HTR1ADRD4HTR2ADRD3 | |
| Ammonia Solution, Strong SCHEMBL7120916 | 0.84 | GFER (0.51) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL8011318 | 0.84 | DRD2 (0.69) | DRD2HTR1ADRD4HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0191867-B1 | TRYCICLIC OR TETRACYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1991-10-16 | — | — | EP | disclosed |
| US-4749703-A | Calcium antagonist piperazine derivatives, and compositions therefor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1988-06-07 | — | — | US | disclosed |
| EP-0191867-A1 | TRYCICLIC OR TETRACYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1986-08-27 | — | — | EP | disclosed |