Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836136 | 0.87 | DAO (0.42) | KDM4EMAOBKMT2ABAZ2BBAZ2A | |
| SCHEMBL9836198 | 0.84 | KDM4E (0.39) | KDM4EMAP2K2MAP2K1MAOBDAPK3 | |
| SCHEMBL9837349 | 0.77 | IKBKB (0.49) | KDM4EKMT2A | |
| SCHEMBL6050600 | 0.73 | KDM4E (0.43) | KDM4EMAP2K2MAP2K1PKMKMT2A | |
| Water SCHEMBL9837052 | 0.72 | KDM4E (0.42) | KDM4EMAP2K2MAP2K1PKMKMT2A | |
| SCHEMBL6050616 | 0.71 | KDM4E (0.56) | KDM4EMAP2K2MAP2K1MAOBDAPK3 | |
| SCHEMBL9835125 | 0.70 | HSD17B10 (0.43) | KDM4EPKMMAOBKMT2ABAZ2B | |
| SCHEMBL11278972 | 0.69 | KDM4E (0.48) | KDM4EPKMKMT2ADAO | |
| SCHEMBL10563397 | 0.67 | MEN1 (0.49) | KDM4EKMT2ATP53 | |
| SCHEMBL10341192 | 0.67 | KDM4E (0.49) | KDM4EMAP2K2MAP2K1MAOBLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269295-B1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1991-06-26 | — | — | EP | disclosed |
| US-4877793-A | CARDIOVASCULAR DISORDERS | THE BOOTS COMPANY, PLC (GB) | 1989-10-31 | — | — | US | disclosed |
| EP-0269295-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1988-06-01 | — | — | EP | disclosed |