Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834409 | 0.87 | KDM4E (0.41) | DAOKMT2AMAOBBAZ2BBAZ2A | |
| SCHEMBL9835125 | 0.83 | HSD17B10 (0.43) | KMT2ALMNAMAOBMEN1BAZ2B | |
| SCHEMBL11278972 | 0.81 | KDM4E (0.48) | DAOKMT2ALMNAMEN1KDM4E | |
| SCHEMBL9837257 | 0.77 | ALDH1A1 (0.46) | KMT2ALMNAMEN1KDM4EPOLB | |
| SCHEMBL11582014 | 0.76 | DAO (0.42) | DAOKMT2ALMNA | |
| SCHEMBL7288734 | 0.72 | KMT2A (0.42) | KMT2ALMNAMEN1POLBTDP1 | |
| SCHEMBL6664480 | 0.72 | LMNA (0.53) | KMT2ALMNAMAOBMEN1KDM4E | |
| SCHEMBL9836198 | 0.70 | KDM4E (0.39) | LMNAMAOBBAZ2BBAZ2AKDM4E | |
| SCHEMBL3663507 | 0.70 | KMT2A (0.55) | KMT2ALMNAMAOBMEN1KDM4E | |
| SCHEMBL392466 | 0.68 | BAZ2B (0.61) | KMT2ALMNAMEN1BAZ2BBAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269295-B1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1991-06-26 | — | — | EP | disclosed |
| US-4877793-A | CARDIOVASCULAR DISORDERS | THE BOOTS COMPANY, PLC (GB) | 1989-10-31 | — | — | US | disclosed |
| EP-0269295-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1988-06-01 | — | — | EP | disclosed |