Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | PARG | Q86W56 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833577 | 0.84 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9835803 | 0.83 | HSP90AA1 (0.40) | KDM4EHSD17B10PDE4APDE4BPDE4C | |
| SCHEMBL9834585 | 0.83 | PDE3B (0.51) | KDM4ELMNAHSD17B10PDE4APDE4B | |
| SCHEMBL9833692 | 0.82 | FABP6 (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9833047 | 0.80 | ALDH1A1 (0.42) | KDM4EHSD17B10PDE4APDE4BPDE4C | |
| SCHEMBL9833945 | 0.79 | KDM4E (0.44) | KDM4ELMNAHSD17B10PDE4APDE4B | |
| SCHEMBL9833659 | 0.79 | LMNA (0.46) | KDM4ELMNAPDE4APDE4BPDE4C | |
| SCHEMBL9834918 | 0.78 | KMT2A (0.45) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10566074 | 0.76 | PDE4A (0.43) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9835143 | 0.76 | PDE4A (0.34) | KDM4EPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |