SCHEMBL9834841

SCHEMBL9834841

O=C(Cl)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.61
GPR35 Q9HC97 1/20 0.58
JUN P05412 3/20 0.57
NFKB1 P19838 3/20 0.57
NFKB2 Q00653 3/20 0.57
RELA Q04206 3/20 0.57
P2RX1 P51575 9/20 0.56
LMNA P02545 1/20 0.56
ACP1 P24666 1/20 0.54
P2RX4 Q99571 3/20 0.51
P2RX7 Q99572 3/20 0.51
TACR1 P25103 1/20 0.51
TMPRSS4 Q9NRS4 2/20 0.51
MEN1 O00255 1/20 0.51
IKBKB O14920 1/20 0.51
CHUK O15111 1/20 0.51
KDR P35968 1/20 0.51
FLT3 P36888 1/20 0.51
KMT2A Q03164 1/20 0.51
MYLK Q15746 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20560661 0.89 XPO1 (0.52) MAPTGPR35JUNNFKB1NFKB2
SCHEMBL7692960 0.83 GPR35 (0.74) MAPTGPR35JUNNFKB1NFKB2
SCHEMBL2681462 0.83 MAPT (0.78) MAPTGPR35P2RX1LMNAACP1
SCHEMBL20560345 0.81 MAPT (0.68) MAPTP2RX1LMNAMEN1KDR
SCHEMBL5833345 0.81 GPR35 (0.66) MAPTGPR35JUNNFKB1NFKB2
SCHEMBL11788448 0.81 MAPT (0.63) MAPTGPR35JUNNFKB1NFKB2
SCHEMBL5773763 0.79 MAPT (0.67) MAPTGPR35P2RX1LMNAACP1
SCHEMBL20560321 0.79 MAPT (0.52) MAPTGPR35JUNNFKB1NFKB2
SCHEMBL4488884 0.79 MAPT (0.61) MAPTGPR35JUNNFKB1NFKB2
SCHEMBL4488889 0.79 MAPT (0.61) MAPTGPR35JUNNFKB1NFKB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3404017-B1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL IND LTD (JP) 2020-05-13 EP disclosed
US-10336686-B2 Fluorine atom-containing compound and use thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-07-02 US disclosed
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-01-31 US disclosed
EP-3404017-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF Nissan Chemical Industries, Ltd. (JP) 2018-11-21 EP disclosed
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed
EP-0015110-B1 ANTICOCCIDIAL COMPOSITION, CARBANILIDES AND METHOD OF PREPARING THEM ELI LILLY AND COMPANY (US) 1985-08-21 EP disclosed
US-4526997-A Amino, nitro, fluoro substituted carbanilides DOHERTY GEORGE O P O 1985-07-02 US disclosed
US-4468380-A Anticoccidial combinations comprising polyether antibiotics and carbanilides ELI LILLY AND COMPANY (US) 1984-08-28 US disclosed
EP-0015110-A2 Anticoccidial composition, carbanilides and method of preparing them ELI LILLY AND COMPANY (US) 1980-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336686-B2 Fluorine atom-containing compound and use thereof ARF1, ARF5, ARFGAP1 MAPT 3103/4885GPR35 968/4885JUN 936/4885
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF ARF1, ARF5, ARFGAP1 MAPT 3103/4885GPR35 968/4885JUN 936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.