Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 11/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836597 | 0.86 | EGFR (0.36) | BRD4BRD2EGFR | |
| SCHEMBL9831955 | 0.78 | PDE3B (0.53) | HPGDPOLBMAPTKDM4EALDH1A1 | |
| SCHEMBL10567700 | 0.77 | BRD4 (0.33) | RAB9ABRD4BRD2 | |
| SCHEMBL10568243 | 0.76 | PDE4A (0.40) | HPGDPOLBMAPTKDM4EALDH1A1 | |
| SCHEMBL9831891 | 0.75 | MAPT (0.54) | HPGDPOLBMAPTKDM4EALDH1A1 | |
| SCHEMBL10373348 | 0.73 | CDK4 (0.40) | BRD4BRD2EGFR | |
| SCHEMBL13041691 | 0.68 | ALDH1A1 (0.59) | HSP90AA1ESR2TDP1HPGDPOLB | |
| SCHEMBL20436361 | 0.67 | BRD4 (0.57) | MAPTKDM4EALDH1A1BRD4BRD2 | |
| SCHEMBL8135807 | 0.67 | HPGD (0.44) | HSP90AA1ESR2TDP1HPGDPOLB | |
| SCHEMBL9835803 | 0.67 | HSP90AA1 (0.40) | HSP90AA1ESR2TDP1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |