Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 6/20 | 0.39 |
| ▸ | ACSL3 | O95573 | 1/20 | 0.39 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.39 |
| ▸ | ACSL6 | Q9UKU0 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834412 | 0.87 | TTR (0.45) | TTRSMN1; SMN2MAOAKDM4EALDH1A1 | |
| SCHEMBL9837053 | 0.86 | TTR (0.49) | TTRSMN1; SMN2MAOAACSL3ACSL1 | |
| SCHEMBL9836749 | 0.85 | SMN1; SMN2 (0.36) | TTRSMN1; SMN2MAOA | |
| SCHEMBL9835296 | 0.82 | TTR (0.52) | TTRSMN1; SMN2MAOAACSL3ACSL1 | |
| SCHEMBL9834130 | 0.77 | TTR (0.52) | TTRSMN1; SMN2MAOAACSL3ACSL1 | |
| SCHEMBL10537230 | 0.77 | TTR (0.44) | TTRSMN1; SMN2MAOAACSL3ACSL1 | |
| SCHEMBL9834701 | 0.75 | MAOA (0.49) | TTRSMN1; SMN2MAOAADORA3KDM4E | |
| SCHEMBL10808391 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10801805 | 0.72 | FFAR4 (0.43) | SMN1; SMN2 | |
| SCHEMBL9837354 | 0.72 | MAOA (0.37) | TTRSMN1; SMN2MAOAKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175376-B1 | XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4816479-A | HYPOTENSIVE AGENTS, DIURETICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1989-03-28 | — | — | US | disclosed |
| US-4661607-A | ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-04-28 | — | — | US | disclosed |