Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834130 | 0.79 | TTR (0.52) | MAOATTRSMN1; SMN2HPGDKDM4E | |
| SCHEMBL9835296 | 0.79 | TTR (0.52) | MAOATTRSMN1; SMN2HPGDKDM4E | |
| SCHEMBL9835513 | 0.78 | MAOA (0.47) | MAOATTRKDM5AIKBKBKDM4E | |
| SCHEMBL10537230 | 0.77 | TTR (0.44) | MAOATTRKDM5ASMN1; SMN2HPGD | |
| SCHEMBL9837053 | 0.75 | TTR (0.49) | MAOATTRSMN1; SMN2HPGDKDM4E | |
| SCHEMBL10871145 | 0.75 | MGAM (0.42) | MAOATTRADORA3SMN1; SMN2HPGD | |
| SCHEMBL9834901 | 0.75 | TTR (0.49) | MAOATTRADORA3SMN1; SMN2HPGD | |
| SCHEMBL9836636 | 0.71 | PTGS2 (0.47) | MAOATTRKDM5ASMN1; SMN2HPGD | |
| SCHEMBL9834412 | 0.69 | TTR (0.45) | MAOATTRSMN1; SMN2HPGDKDM4E | |
| SCHEMBL9834940 | 0.68 | TTR (0.46) | MAOATTRSMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175376-B1 | XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4816479-A | HYPOTENSIVE AGENTS, DIURETICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1989-03-28 | — | — | US | disclosed |
| US-4661607-A | ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-04-28 | — | — | US | disclosed |