Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 15/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834236 | 0.80 | AURKA (0.51) | PGRAURKAAURKBPDE4APDE4B | |
| SCHEMBL9832737 | 0.74 | AURKA (0.36) | PGRAURKAAURKBPDE4APDE4B | |
| SCHEMBL10560992 | 0.73 | AURKA (0.35) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL9834204 | 0.70 | AURKA (0.33) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL9833966 | 0.70 | MAPT (0.40) | PGRAURKAAURKBHTR7LMNA | |
| SCHEMBL9832258 | 0.69 | PGR (0.47) | PGRHTR7LMNAHTR1ADRD2 | |
| SCHEMBL16315854 | 0.68 | PGR (0.56) | PGRHTR7LMNA | |
| SCHEMBL9833260 | 0.68 | PGR (0.39) | PGRAURKAAURKBPDE4APDE4B | |
| SCHEMBL1696201 | 0.67 | PGR (0.55) | PGRLMNA | |
| SCHEMBL9834118 | 0.67 | PGR (0.44) | PGRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257334-B1 | TRICYCLIC BENZOTRIAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1991-01-02 | — | — | EP | disclosed |
| US-4835167-A | Tricyclic benzotriazoles, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| EP-0257334-A2 | Tricyclic benzotriazoles, process for their preparation and medicaments | Roche Diagnostics GmbH (DE) | 1988-03-02 | — | — | EP | disclosed |