Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834236 | 0.81 | AURKA (0.51) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10560992 | 0.77 | AURKA (0.35) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL9833671 | 0.71 | AURKA (0.40) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL9832263 | 0.71 | PGR (0.33) | PGR | |
| SCHEMBL9834204 | 0.71 | AURKA (0.33) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL9833260 | 0.69 | PGR (0.39) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL9833677 | 0.68 | PGR (0.32) | PGR | |
| SCHEMBL28294093 | 0.66 | PGR (0.34) | PGR | |
| SCHEMBL9833020 | 0.65 | PDE4A (0.66) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL9833556 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257334-B1 | TRICYCLIC BENZOTRIAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1991-01-02 | — | — | EP | disclosed |
| US-4835167-A | Tricyclic benzotriazoles, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| EP-0257334-A2 | Tricyclic benzotriazoles, process for their preparation and medicaments | Roche Diagnostics GmbH (DE) | 1988-03-02 | — | — | EP | disclosed |