Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833982 | 0.90 | NR3C1 (0.57) | NR3C1PDE4BPGRPDE5A | |
| SCHEMBL9833383 | 0.88 | NR3C1 (0.55) | NR3C1PDE4BPGRPDE5A | |
| SCHEMBL10756868 | 0.88 | NR3C1 (0.54) | NR3C1PDE4BPGRALDH1A1HPGD | |
| SCHEMBL9835965 | 0.87 | NR3C1 (0.60) | NR3C1PDE4BPGRPDE5A | |
| SCHEMBL9834161 | 0.86 | PDE4B (0.60) | NR3C1PDE4BPGRHPGDPDE5A | |
| SCHEMBL9833323 | 0.86 | NR3C1 (0.53) | NR3C1PDE4BPGRALDH1A1PDE5A | |
| SCHEMBL9835287 | 0.82 | NR3C1 (0.67) | NR3C1PDE4BPGR | |
| SCHEMBL9834976 | 0.81 | NR3C1 (0.67) | NR3C1PDE4BPGRHPGDPDE5A | |
| SCHEMBL9836172 | 0.81 | NR3C1 (0.55) | NR3C1PDE4BPGRPDE5A | |
| SCHEMBL10758282 | 0.80 | NR3C1 (0.48) | NR3C1PDE4BPGRPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230016-B1 | 6H-Isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4624955-A | 6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, method for their preparation and use as anxiolytic agents | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1986-11-25 | — | — | US | disclosed |