Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835287 | 0.91 | NR3C1 (0.67) | PDE4BNR3C1PGR | |
| SCHEMBL9836172 | 0.89 | NR3C1 (0.55) | PDE4BNR3C1PGRPDE5A | |
| SCHEMBL9835965 | 0.89 | NR3C1 (0.60) | PDE4BNR3C1PGRPDE5A | |
| SCHEMBL9835355 | 0.87 | PDE4B (0.55) | PDE4BNR3C1PGRPDE5AMAPT | |
| SCHEMBL10755398 | 0.86 | PDE4B (0.47) | PDE4BNR3C1PGRPDE5AMEN1 | |
| SCHEMBL9834731 | 0.86 | NR3C1 (0.55) | PDE4BNR3C1PGRMAPT | |
| SCHEMBL9835196 | 0.86 | NR3C1 (0.67) | PDE4BNR3C1PGRPDE5AHPGD | |
| SCHEMBL9833982 | 0.82 | NR3C1 (0.57) | PDE4BNR3C1PGRPDE5A | |
| SCHEMBL9834976 | 0.82 | NR3C1 (0.67) | PDE4BNR3C1PGRPDE5AMEN1 | |
| SCHEMBL9833383 | 0.81 | NR3C1 (0.55) | PDE4BNR3C1PGRPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230016-B1 | 6H-Isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4624955-A | 6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, method for their preparation and use as anxiolytic agents | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1986-11-25 | — | — | US | disclosed |