Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8478547 | 0.86 | SMN1; SMN2 (0.62) | KMT2ASMN1; SMN2GAAPOLBPDE5A | |
| SCHEMBL9835391 | 0.84 | SMN1; SMN2 (0.68) | KMT2ASMN1; SMN2GAAPOLBPDE5A | |
| SCHEMBL9836846 | 0.82 | PDE5A (0.64) | KMT2ASMN1; SMN2GAAPOLBPDE5A | |
| SCHEMBL9836320 | 0.81 | SMN1; SMN2 (0.63) | KMT2ASMN1; SMN2GAAPOLBPDE5A | |
| SCHEMBL9677782 | 0.81 | SMN1; SMN2 (0.71) | KMT2ASMN1; SMN2GAAPOLBPDE5A | |
| SCHEMBL4685246 | 0.81 | PDE5A (0.70) | KMT2ASMN1; SMN2GAAPOLBPDE5A | |
| SCHEMBL307301 | 0.77 | SMN1; SMN2 (1.00) | KMT2ASMN1; SMN2ALDH1A1L3MBTL1CDK5 | |
| SCHEMBL9836233 | 0.77 | SMN1; SMN2 (0.66) | KMT2ASMN1; SMN2GAAPDE5AALDH1A1 | |
| SCHEMBL353851 | 0.76 | SMN1; SMN2 (0.73) | KMT2ASMN1; SMN2GAAPOLBPDE5A | |
| SCHEMBL9835719 | 0.75 | SMN1; SMN2 (0.71) | KMT2ASMN1; SMN2GAAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224919-B1 | NEW THIAZOLE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4742057-A | Antiallergic thiazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |