Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685246 | 0.96 | PDE5A (0.70) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL9835391 | 0.91 | SMN1; SMN2 (0.68) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL20935220 | 0.87 | PDE5A (0.66) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL9677782 | 0.85 | SMN1; SMN2 (0.71) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL91408 | 0.84 | PDE5A (0.74) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL93110 | 0.83 | PDE5A (0.76) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL10084854 | 0.83 | PDE5A (0.57) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL9835472 | 0.82 | KMT2A (0.62) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL8478547 | 0.82 | SMN1; SMN2 (0.62) | PDE5ASMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL4099160 | 0.81 | PDE5A (0.58) | PDE5ASMN1; SMN2GAAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224919-B1 | NEW THIAZOLE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4742057-A | Antiallergic thiazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |