Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | PDE5A | O76074 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 2/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597160 | 0.85 | ALDH1A1 (0.50) | SMN1; SMN2KMT2AALDH1A1HPGDPDE5A | |
| SCHEMBL9677782 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2KMT2AALDH1A1HPGDPDE5A | |
| SCHEMBL69505 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL9835391 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AALDH1A1PDE5AKDM4E | |
| SCHEMBL12921418 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL307301 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL77191 | 0.79 | ALDH1A1 (0.63) | SMN1; SMN2KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL9836846 | 0.78 | PDE5A (0.64) | SMN1; SMN2KMT2AALDH1A1HPGDPDE5A | |
| SCHEMBL356279 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL353851 | 0.78 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2AALDH1A1HPGDPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224919-B1 | NEW THIAZOLE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4742057-A | Antiallergic thiazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |