Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.42 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 5/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | MDH2 | P40926 | 4/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836107 | 0.77 | CYP1A2 (0.45) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL7837299 | 0.73 | ALDH1A1 (0.61) | PDE4DPDE4APDE4BPDE4CFASN | |
| SCHEMBL624796 | 0.73 | PKM (0.58) | PDE4DPDE4APDE4BPDE4CFASN | |
| SCHEMBL10626074 | 0.71 | CRBN (0.55) | ALDH1A1MAPT | |
| SCHEMBL22491426 | 0.70 | CA12 (0.47) | ALDH1A1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL22491481 | 0.69 | CRBN (0.48) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL29734435 | 0.69 | CRBN (0.48) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL3389331 | 0.69 | EPHX2 (0.61) | — | |
| SCHEMBL6600362 | 0.68 | CTNNB1 (0.71) | PDE4DPDE4APDE4BPDE4CTHRA | |
| SCHEMBL30313764 | 0.68 | CTNNB1 (0.71) | PDE4DPDE4APDE4BPDE4CTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |