Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491452 | 0.94 | AR (0.53) | ARTSHRNPC1MAPK1CYP1A2 | |
| SCHEMBL6491459 | 0.94 | AR (0.53) | ARTSHRNPC1MAPK1CYP1A2 | |
| SCHEMBL9774699 | 0.94 | AR (0.53) | ARTSHRNPC1MAPK1CYP1A2 | |
| SCHEMBL5010945 | 0.91 | AR (0.56) | ARTSHRMAPK1CYP1A2KDM4E | |
| SCHEMBL4049993 | 0.86 | TSHR (0.51) | TSHRNPC1LMNACACNA1GKCNH2 | |
| SCHEMBL6228324 | 0.84 | AR (0.61) | ARTSHRMAPK1CYP1A2KDM4E | |
| SCHEMBL8994531 | 0.84 | TSHR (0.56) | ARTSHRMAPK1CYP1A2KDM4E | |
| SCHEMBL15500156 | 0.84 | PTGS1 (0.54) | ARTSHRMAPK1MEN1KMT2A | |
| SCHEMBL1496800 | 0.84 | TSHR (0.56) | ARTSHRMAPK1CYP1A2KDM4E | |
| SCHEMBL14901498 | 0.82 | AR (0.69) | ARTSHRMAPK1CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276196-B1 | SUBSTITUTED DIOXOLANE DERIVATIVES | CIBA-GEIGY AG (CH) | 1991-09-18 | — | — | EP | disclosed |
| US-4971981-A | PESTICIDES, INSECTICIDES, LARVICIDES | CIBA-GEIGY CORPORATION (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0276196-A1 | Substituted dioxolane derivatives | CIBA-GEIGY AG (CH) | 1988-07-27 | — | — | EP | disclosed |