Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994116 | 0.72 | ALDH1A1 (0.46) | XDHLMNATSHRADORA2ASLC6A4 | |
| SCHEMBL10765282 | 0.66 | XDH (0.40) | XDHRETPI4KALRRK2PI4K2B | |
| SCHEMBL20584461 | 0.64 | KMT2A (0.52) | LMNACDK2ALDH1A1MAPK1MKNK1 | |
| SCHEMBL11607575 | 0.60 | XDH (0.71) | XDHRETPI4KALRRK2PI4K2B | |
| SCHEMBL21662935 | 0.59 | PDPK1 (0.46) | XDHRETPI4KALRRK2PI4K2B | |
| SCHEMBL20176622 | 0.58 | XDH (0.44) | XDHRETPI4KALRRK2PI4K2B | |
| SCHEMBL2045752 | 0.57 | MAPT (0.40) | RETLRRK2TSHRBLMSMN1; SMN2 | |
| SCHEMBL24802934 | 0.57 | CCNT1 (0.42) | XDHRETPI4KALRRK2PI4K2B | |
| SCHEMBL13705860 | 0.57 | XDH (0.52) | XDHRETPI4KALRRK2PI4K2B | |
| SCHEMBL23858513 | 0.57 | CCNT1 (0.42) | XDHRETPI4KALRRK2PI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230016-B1 | 6H-Isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-09-11 | — | — | EP | disclosed |
| EP-0230016-A1 | 6H-Isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-07-29 | — | — | EP | disclosed |
| US-4624955-A | 6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, method for their preparation and use as anxiolytic agents | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1986-11-25 | — | — | US | disclosed |