Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 4/20 | 0.40 |
| ▸ | CMA1 | P23946 | 2/20 | 0.40 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31726677 | 0.94 | PGR (0.46) | PGRTDP2AHRCMA1ESPL1 | |
| SCHEMBL21646065 | 0.79 | KIF11 (0.44) | PGRESPL1ATMTDP1KIF11 | |
| SCHEMBL30806271 | 0.79 | KIF11 (0.44) | PGRESPL1ATMTDP1KIF11 | |
| SCHEMBL548762 | 0.79 | AHR (0.50) | PGRTDP2AHRCMA1PDE3B | |
| SCHEMBL4507222 | 0.77 | MAPT (0.49) | PGRTDP2AHRCMA1PDE3B | |
| SCHEMBL9832978 | 0.77 | PGR (0.46) | PGRTDP2AHRCMA1TDP1 | |
| SCHEMBL31726573 | 0.77 | AHR (0.47) | PGRTDP2AHRCMA1EIF2AK2 | |
| SCHEMBL31727303 | 0.77 | MAPT (0.49) | PGRTDP2AHRCMA1PDE3B | |
| SCHEMBL5502745 | 0.77 | PGR (0.46) | PGRTDP2AHRCMA1TDP1 | |
| SCHEMBL8647059 | 0.77 | AHR (0.47) | PGRTDP2AHRCMA1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |