Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 5/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.40 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.40 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10712589 | 0.77 | GRIA1 (0.52) | TDP2GRIA1CACNG8CACNG2AHR | |
| SCHEMBL3255662 | 0.75 | SMYD3 (0.53) | ALDH1A1AKR1C3AKR1C2AKR1C1TDP2 | |
| SCHEMBL9834029 | 0.73 | CYP2C8 (0.39) | ALDH1A1AKR1C3AKR1C2AKR1C1TDP2 | |
| SCHEMBL11459814 | 0.73 | GRM5 (0.46) | ALDH1A1TDP2ATMCNR1CNR2 | |
| SCHEMBL11459055 | 0.73 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1 | |
| SCHEMBL3655586 | 0.73 | GRIA1 (0.37) | GRIA1CACNG8CACNG2CRBNAHR | |
| SCHEMBL29245505 | 0.72 | PDE5A (0.36) | ALDH1A1ATMTDP1L3MBTL1CNR1 | |
| SCHEMBL9667584 | 0.72 | SMYD3 (0.53) | ALDH1A1AKR1C3AKR1C2AKR1C1TDP2 | |
| SCHEMBL7679044 | 0.72 | SMYD3 (0.53) | ALDH1A1AKR1C3AKR1C2AKR1C1TDP2 | |
| SCHEMBL20424765 | 0.72 | THRB (0.37) | ALDH1A1TDP2GRIA1CACNG8CACNG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |
| CN-86105309-A | Oxindole-3-carbonyl amines the compound that replaces as the 1-of anti-inflammatory and anodyne | — | 1987-01-14 | — | — | CN | disclosed |