SCHEMBL9835927

SCHEMBL9835927

O=C(Cl)Nc1cc(C(F)(F)F)ccc1F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TMPRSS4 Q9NRS4 2/20 0.61
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
TSHR P16473 1/20 0.60
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA9 Q16790 1/20 0.53
KDR P35968 4/20 0.50
TRPV1 Q8NER1 1/20 0.50
CHRNA7 P36544 1/20 0.47
NTRK1 P04629 2/20 0.46
RET P07949 2/20 0.46
PDGFRB P09619 2/20 0.46
CDK8 P49336 2/20 0.46
NTRK3 Q16288 2/20 0.46
MAPK14 Q16539 2/20 0.46
NTRK2 Q16620 2/20 0.46
PDGFRA P16234 1/20 0.46
LTK P29376 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3618813 0.84 MEN1 (0.61) TMPRSS4MEN1KMT2ATSHRCA12
SCHEMBL12126017 0.83 MEN1 (0.60) TMPRSS4MEN1KMT2ATSHRCA12
SCHEMBL20560277 0.83 MEN1 (0.55) TMPRSS4MEN1KMT2ATSHRCA12
SCHEMBL30977684 0.83 MEN1 (0.60) TMPRSS4MEN1KMT2ATSHRCA12
SCHEMBL60290 0.83 KIF11 (0.63) TMPRSS4MEN1KMT2ATSHRCA12
SCHEMBL9835452 0.83 CHRNA7 (0.61) MEN1KMT2ATSHRTRPV1CHRNA7
SCHEMBL29572624 0.83 KIF11 (0.63) TMPRSS4MEN1KMT2ATSHRCA12
SCHEMBL4002473 0.82 TMPRSS4 (0.57) TMPRSS4MEN1KMT2ATSHRCA12
SCHEMBL18205840 0.80 MEN1 (0.57) TMPRSS4MEN1KMT2ATSHRCA12
SCHEMBL19669082 0.80 MEN1 (0.57) TMPRSS4MEN1KMT2ATSHRCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3404017-B1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL IND LTD (JP) 2020-05-13 EP disclosed
US-10336686-B2 Fluorine atom-containing compound and use thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-07-02 US disclosed
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-01-31 US disclosed
EP-3404017-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF Nissan Chemical Industries, Ltd. (JP) 2018-11-21 EP disclosed
CN-108698982-A FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF 日产化学工业株式会社 2018-10-23 CN disclosed
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336686-B2 Fluorine atom-containing compound and use thereof ARF1, ARF5, ARFGAP1 TMPRSS4 4473/4885MEN1 755/4885KMT2A 1622/4885
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF ARF1, ARF5, ARFGAP1 TMPRSS4 4473/4885MEN1 755/4885KMT2A 1622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.