SCHEMBL9835974

SCHEMBL9835974

O=C(Cl)Nc1cccc(Cl)c1Cl

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 9/20 0.69
KMT2A Q03164 9/20 0.69
LMNA P02545 3/20 0.61
MAPT P10636 3/20 0.61
MAPK1 P28482 1/20 0.59
NPC1 O15118 1/20 0.56
HPGD P15428 1/20 0.56
RAB9A P51151 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
KDM4E B2RXH2 1/20 0.56
ALDH1A1 P00352 1/20 0.56
PDK1 Q15118 1/20 0.54
PDK2 Q15119 1/20 0.54
PDK3 Q15120 1/20 0.54
PDK4 Q16654 1/20 0.54
GPR35 Q9HC97 1/20 0.52
TSHR P16473 1/20 0.51
CYP1A2 P05177 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10710090 0.85 MEN1 (0.79) MEN1KMT2ALMNAMAPTMAPK1
SCHEMBL2094293 0.83 MEN1 (0.69) MEN1KMT2ALMNAMAPTMAPK1
SCHEMBL665304 0.83 MEN1 (0.69) MEN1KMT2ALMNAMAPTMAPK1
SCHEMBL2008072 0.82 MEN1 (1.00) MEN1KMT2ALMNAMAPTMAPK1
SCHEMBL11789624 0.82 MEN1 (0.67) MEN1KMT2ALMNAMAPTMAPK1
Fluoride SCHEMBL11789630 0.82 MEN1 (0.67) MEN1KMT2ALMNAMAPTMAPK1
SCHEMBL2068768 0.82 LMNA (0.68) MEN1KMT2ALMNAMAPTMAPK1
SCHEMBL30623497 0.82 MEN1 (0.67) MEN1KMT2ALMNAMAPTMAPK1
SCHEMBL3612815 0.82 MEN1 (0.67) MEN1KMT2ALMNAMAPTMAPK1
SCHEMBL20560605 0.80 GPR35 (0.48) MEN1KMT2ANPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed