Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12725183 | 0.98 | PTGS2 (0.49) | PTGS2HSD17B10CYP2D6CYP2C9HPGD | |
| SCHEMBL10050131 | 0.89 | PTGS2 (0.42) | PTGS2HSD17B10CYP2D6CYP2C9HPGD | |
| SCHEMBL15681729 | 0.89 | PTGS2 (0.42) | PTGS2HSD17B10CYP2D6CYP2C9HPGD | |
| SCHEMBL7067426 | 0.89 | PTGS2 (0.42) | PTGS2HSD17B10CYP2D6CYP2C9HPGD | |
| SCHEMBL12725190 | 0.84 | PTGS2 (0.40) | PTGS2HSD17B10CYP2D6CYP2C9HPGD | |
| SCHEMBL5070001 | 0.82 | NR1H2 (0.52) | PTGS2MAPTTDP1MGLLNR1H2 | |
| SCHEMBL29644702 | 0.81 | PTGS2 (0.69) | PTGS2HSD17B10CYP2D6CYP2C9HPGD | |
| SCHEMBL14757412 | 0.80 | EGFR (0.38) | PTGS2HSD17B10HPGDMAPTTDP1 | |
| SCHEMBL16456169 | 0.80 | SENP1 (0.45) | PTGS2APPALDH1A1 | |
| SCHEMBL12725181 | 0.80 | NR1H2 (0.50) | PTGS2CTRCMAPTMGLLNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133156-B1 | 1,4-DIKETOPYRROLO-(3,4-C) PYRROLES | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | disclosed |
| US-4666455-A | Compositions pigmented with N-substituted 1,4-diketopyrrolo-[3,4-c]-pyrroles | CIBA-GEIGY CORPORATION (US) | 1987-05-19 | — | — | US | disclosed |
| US-4585878-A | N-substituted 1,4-diketopyrrolo-[3,4-c]-pyrroles | CIBA-GEIGY CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |