Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835827 | 0.79 | KDM4E (0.50) | LMNAKDM4EMAPTALDH1A1CYSLTR2 | |
| SCHEMBL11549881 | 0.71 | LMNA (0.62) | LMNAKDM4EMAPTALDH1A1CYSLTR2 | |
| SCHEMBL9836044 | 0.69 | CYSLTR2 (0.61) | LMNAKDM4EMAPTALDH1A1CYSLTR2 | |
| SCHEMBL9836037 | 0.69 | CYSLTR2 (0.61) | LMNAKDM4EMAPTALDH1A1CYSLTR2 | |
| Chimanine B SCHEMBL4623624 | 0.68 | LMNA (0.55) | LMNAKDM4EMAPTALDH1A1CYSLTR2 | |
| SCHEMBL5093238 | 0.68 | KDM4E (0.69) | LMNAKDM4EMAPTALDH1A1CYSLTR2 | |
| SCHEMBL5093226 | 0.68 | KDM4E (0.69) | LMNAKDM4EMAPTALDH1A1CYSLTR2 | |
| SCHEMBL6070329 | 0.68 | GAA (0.41) | LMNAKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL372572 | 0.67 | LMNA (1.00) | LMNAKDM4EMAPTALDH1A1CYSLTR2 | |
| SCHEMBL902324 | 0.67 | LMNA (1.00) | LMNAKDM4EMAPTALDH1A1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219308-B1 | 2-SUBSTITUTED QUINOLINES | MERCK FROSST CANADA INC. (CA) | 1991-10-23 | — | — | EP | claimed |
| EP-0219308-B1 | 2-SUBSTITUTED QUINOLINES | MERCK FROSST CANADA INC. (CA) | 1991-10-23 | — | — | EP | disclosed |