Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8447584 | 0.86 | CES2 (0.46) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL8448905 | 0.86 | CES2 (0.46) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL19689338 | 0.82 | TDP1 (0.44) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL19689337 | 0.82 | TDP1 (0.44) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL8447125 | 0.79 | CES2 (0.48) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL9836350 | 0.76 | TDP1 (0.44) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL9836356 | 0.76 | FOLH1 (0.44) | TDP1KMT2AALDH1A1TSHRATM | |
| SCHEMBL9838376 | 0.75 | CYP1A2 (0.42) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL10571054 | 0.75 | POLB (0.43) | KMT2AMEN1 | |
| SCHEMBL9269862 | 0.73 | TDP1 (0.55) | TDP1KMT2AMAPK1HIF1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159264-B1 | ANTIVIRAL COMPOUNDS | MERCK & CO. INC. (US) | 1991-07-24 | — | — | EP | disclosed |
| US-4859680-A | Pyrimidine derivatives as antiviral compounds | MERCK & CO., INC. (US) | 1989-08-22 | — | — | US | disclosed |
| US-4617304-A | VIRICIDE; HERPES | MERCK & CO., INC. (US) | 1986-10-14 | — | — | US | disclosed |
| EP-0159264-A2 | Antiviral compounds | MERCK & CO. INC. (US) | 1985-10-23 | — | — | EP | disclosed |