Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | GABRP | O00591 | 4/20 | 0.58 |
| ▸ | GABRD | O14764 | 4/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.58 |
| ▸ | GABRE | P78334 | 4/20 | 0.58 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835460 | 0.81 | MEN1 (0.55) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9835013 | 0.79 | GABRA1 (0.51) | MEN1KMT2ANPC1RAB9AGABRA1 | |
| SCHEMBL4780133 | 0.78 | MEN1 (1.00) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9835612 | 0.77 | GABRA1 (0.49) | MEN1KMT2ANPC1RAB9AGABRA1 | |
| SCHEMBL6755465 | 0.77 | KMT2A (0.62) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9835171 | 0.76 | GABRA1 (0.54) | MEN1KMT2ANPC1RAB9AGABRA1 | |
| SCHEMBL9148621 | 0.75 | MEN1 (0.81) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL2943869 | 0.74 | GABRA1 (0.59) | NPC1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL9836096 | 0.74 | GABRA1 (0.55) | MEN1KMT2ANPC1RAB9AGABRA1 | |
| SCHEMBL9836105 | 0.74 | GABRA1 (0.53) | NPC1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217737-B1 | TETRAHYDRO-BETA-CARBOLINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | claimed |
| US-4855295-A | Tetrahydro-beta-carbolines, and their use as drugs | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-08-08 | — | — | US | disclosed |