Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836718 | 0.87 | PDE4B (0.48) | PDE4B | |
| SCHEMBL9836753 | 0.84 | PDE4B (0.48) | MAPTSMN1; SMN2PDE4BPDE5AKDM4E | |
| SCHEMBL2772405 | 0.84 | PDE4B (0.65) | MAPTSMN1; SMN2PDE4BPDE5AKDM4E | |
| SCHEMBL10961214 | 0.83 | MEN1 (0.48) | MAPTSMN1; SMN2MEN1BLMPMP22 | |
| SCHEMBL4336531 | 0.80 | MAPT (0.71) | MAPTSMN1; SMN2PDE4BPDE5AKDM4E | |
| SCHEMBL9838365 | 0.80 | PDE4B (0.48) | MAPTSMN1; SMN2PDE4BPDE5AKDM4E | |
| SCHEMBL4341887 | 0.77 | PDE4B (0.62) | MAPTSMN1; SMN2PDE4BKMT2A | |
| SCHEMBL8284895 | 0.74 | PDE4B (0.49) | MAPTSMN1; SMN2PDE4BPDE5AKDM4E | |
| SCHEMBL9836742 | 0.74 | MAPT (0.51) | MAPTSMN1; SMN2PDE4BPDE5AKDM4E | |
| SCHEMBL9836700 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180318-B1 | AMIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1991-11-06 | — | — | EP | disclosed |
| US-4745121-A | AMINE OR CARBOXAMIDE SUBSTITUTED | ICI AMERICAS INC. (US) | 1988-05-17 | — | — | US | disclosed |
| EP-0180318-A1 | Amide derivatives | ICI AMERICAS INC. (US) | 1986-05-07 | — | — | EP | disclosed |