Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336531 | 0.82 | MAPT (0.71) | MAPTSMN1; SMN2KDM4EPDE4BNPC1 | |
| SCHEMBL2772405 | 0.81 | PDE4B (0.65) | MAPTSMN1; SMN2KDM4EPDE4BNPC1 | |
| SCHEMBL9838365 | 0.80 | PDE4B (0.48) | MAPTSMN1; SMN2KDM4EPDE4BPDE5A | |
| SCHEMBL29170030 | 0.75 | ALDH1A1 (0.59) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL4341887 | 0.74 | PDE4B (0.62) | MAPTSMN1; SMN2PDE4BKMT2A | |
| SCHEMBL9836698 | 0.74 | MAPT (0.49) | MAPTSMN1; SMN2KDM4EPDE4BPDE5A | |
| SCHEMBL9836753 | 0.73 | PDE4B (0.48) | MAPTSMN1; SMN2KDM4EPDE4BPDE5A | |
| SCHEMBL8284895 | 0.71 | PDE4B (0.49) | MAPTSMN1; SMN2KDM4EPDE4BPDE5A | |
| SCHEMBL5504475 | 0.69 | KMT2A (0.62) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL9836656 | 0.68 | PDE4B (0.53) | MAPTPDE4BPDE5AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180318-B1 | AMIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1991-11-06 | — | — | EP | disclosed |
| US-4745121-A | AMINE OR CARBOXAMIDE SUBSTITUTED | ICI AMERICAS INC. (US) | 1988-05-17 | — | — | US | disclosed |
| EP-0180318-A1 | Amide derivatives | ICI AMERICAS INC. (US) | 1986-05-07 | — | — | EP | disclosed |