Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10997351 | 0.88 | KMT2A (0.46) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL9837120 | 0.86 | KDM4E (0.44) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL4896376 | 0.84 | MAPK1 (0.43) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL6491371 | 0.84 | MAP3K8 (0.50) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL11578876 | 0.81 | MAPT (0.49) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL9837084 | 0.79 | ALDH1A1 (0.56) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL483292 | 0.76 | ALDH1A1 (0.47) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL4902910 | 0.75 | KMT2A (0.44) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL2799946 | 0.75 | KMT2A (0.45) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL29810251 | 0.75 | KMT2A (0.45) | KMT2AMEN1KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046990-A2 | 2-Halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno(3,2-b)-pyridine-6-carboxylic acids, salts thereof at the carboxyl group, pharmaceutical use thereof, and intermediates thereof | KANEBO, LTD. (JP) | 1982-03-10 | — | — | EP | claimed |
| EP-0269295-B1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1991-06-26 | — | — | EP | disclosed |
| US-4877793-A | CARDIOVASCULAR DISORDERS | THE BOOTS COMPANY, PLC (GB) | 1989-10-31 | — | — | US | disclosed |
| EP-0046990-A2 | 2-Halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno(3,2-b)-pyridine-6-carboxylic acids, salts thereof at the carboxyl group, pharmaceutical use thereof, and intermediates thereof | KANEBO, LTD. (JP) | 1982-03-10 | — | — | EP | disclosed |