Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | STK17B | O94768 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837120 | 0.81 | KDM4E (0.44) | ALDH1A1SMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL4896376 | 0.79 | MAPK1 (0.43) | ALDH1A1SMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL9836815 | 0.79 | KMT2A (0.43) | ALDH1A1SMN1; SMN2MAPTHPGDHSD17B10 | |
| SCHEMBL6491371 | 0.79 | MAP3K8 (0.50) | ALDH1A1SMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL483292 | 0.74 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL11666684 | 0.74 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL976420 | 0.73 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL29366579 | 0.73 | KMT2A (0.63) | ALDH1A1SMN1; SMN2MAPTRAB9AGAA | |
| SCHEMBL393627 | 0.73 | KMT2A (0.63) | ALDH1A1SMN1; SMN2MAPTRAB9AGAA | |
| SCHEMBL10517750 | 0.73 | MAPT (0.50) | ALDH1A1SMN1; SMN2MAPTHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269295-B1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1991-06-26 | — | — | EP | disclosed |
| US-4877793-A | CARDIOVASCULAR DISORDERS | THE BOOTS COMPANY, PLC (GB) | 1989-10-31 | — | — | US | disclosed |