Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6351039 | 0.83 | MAPT (0.59) | MAPTTDP1POLBMEN1KMT2A | |
| SCHEMBL9863084 | 0.83 | MAPK1 (0.45) | MAPTPOLBALDH1A1ALOX15TSHR | |
| SCHEMBL9835773 | 0.83 | MAPT (0.46) | MAPTTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL2335563 | 0.81 | MAPT (0.40) | MAPTTDP1POLBMEN1KMT2A | |
| SCHEMBL2335559 | 0.81 | MAPT (0.40) | MAPTTDP1POLBMEN1KMT2A | |
| SCHEMBL5611161 | 0.79 | NOTUM (0.44) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL2335555 | 0.77 | GAA (0.51) | MAPTPOLBALDH1A1LMNAHTT | |
| SCHEMBL9003739 | 0.77 | SMN1; SMN2 (0.54) | MAPTTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL737722 | 0.76 | MAPT (1.00) | MAPTTDP1POLBMEN1KMT2A | |
| SCHEMBL29409289 | 0.76 | MAPT (1.00) | MAPTTDP1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261478-B1 | 4,5-DIHYDRO-OXAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1991-04-24 | — | — | EP | disclosed |
| EP-0261478-A1 | 4,5-Dihydro-oxazole derivatives, process for their preparation and their use | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1988-03-30 | — | — | EP | disclosed |