Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10817411 | 0.91 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPTRAB9A | |
| SCHEMBL9839402 | 0.91 | ALDH1A1 (0.57) | ALDH1A1KDM4EHSD17B10MAPTRAB9A | |
| SCHEMBL9691628 | 0.89 | KDM4E (0.47) | ALDH1A1KDM4EHPGD | |
| SCHEMBL9637845 | 0.87 | ALDH1A1 (0.62) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL9839106 | 0.86 | ALDH1A1 (0.47) | ALDH1A1KDM4EHSD17B10MAPTRAB9A | |
| SCHEMBL9691230 | 0.86 | KDM4E (0.46) | ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL9690779 | 0.86 | KDM4E (0.46) | ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL9691684 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4EHSD17B10MAPTRAB9A | |
| SCHEMBL10652934 | 0.84 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPTRAB9A | |
| SCHEMBL9691221 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231511-B1 | 4-AMINOARYLDIHYDROPYRIDINE LACTONES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AG (DE) | 1991-04-10 | — | — | EP | disclosed |
| EP-0231511-A1 | 4-Aminoaryldihydropyridine lactones, process for their preparation and their use in medicaments | BAYER AG (DE) | 1987-08-12 | — | — | EP | disclosed |