Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.61 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 14/20 | 0.56 |
| ▸ | TOP2A | P11388 | 2/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412149 | 0.92 | CACNA1F (0.71) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL8559736 | 0.89 | MEN1 (0.51) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL10542768 | 0.88 | CACNA1F (0.67) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL9837622 | 0.88 | POLB (0.61) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL28454245 | 0.87 | KCNH2 (0.59) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL9837385 | 0.86 | POLB (0.45) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL9368503 | 0.85 | POLB (0.69) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL10339251 | 0.85 | KCNH2 (0.85) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL7812725 | 0.84 | CACNA1F (0.57) | POLBCACNA1FMAPK1CACNA1DKCNH2 | |
| SCHEMBL9167285 | 0.84 | POLB (0.57) | POLBCACNA1FMAPK1CACNA1DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1013114-B | Amino and the 5-hydroxyl-6 of 5-, 8-two fluoroquinolone antibacterial agent preparation method of composition | WARNER LAMBERT CO (US) | 1991-07-10 | — | — | CN | claimed |
| EP-0226961-B1 | 5-AMINO AND 5-HYDROXY-6,8-DIFLUOROQUINOLONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | claimed |
| US-4977154-A | 7-PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1990-12-11 | — | — | US | claimed |
| CN-86108942-A | Amino and the 5-hydroxyl-6 as the 5-of antimicrobial drug, 8-two fluoroquinolones | — | 1987-11-04 | — | — | CN | claimed |
| EP-0226961-A1 | 5-Amino and 5-hydroxy-6,8-difluoroquinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1987-07-01 | — | — | EP | claimed |
| EP-0226961-B1 | 5-AMINO AND 5-HYDROXY-6,8-DIFLUOROQUINOLONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4977154-A | 7-PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| CN-86108942-A | Amino and the 5-hydroxyl-6 as the 5-of antimicrobial drug, 8-two fluoroquinolones | — | 1987-11-04 | — | — | CN | disclosed |
| EP-0226961-A1 | 5-Amino and 5-hydroxy-6,8-difluoroquinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1987-07-01 | — | — | EP | disclosed |