Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317490 | 0.71 | BAZ2B (0.47) | TSHRHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL6318668 | 0.68 | BAZ2B (0.43) | TSHRMAPK1HPGDMEN1KMT2A | |
| SCHEMBL6050600 | 0.65 | KDM4E (0.43) | MAPK1MEN1KMT2AALDH1A1PKM | |
| SCHEMBL11461755 | 0.65 | TSHR (0.47) | TSHRMAPK1HPGDMEN1KMT2A | |
| Water SCHEMBL9837052 | 0.64 | KDM4E (0.42) | MAPK1MEN1KMT2AALDH1A1PKM | |
| SCHEMBL28716765 | 0.63 | TSHR (0.62) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL9836198 | 0.61 | KDM4E (0.39) | ALDH1A1LMNAKDM4EBAZ2BBAZ2A | |
| SCHEMBL9834409 | 0.60 | KDM4E (0.41) | MAPK1KMT2APKMKDM4EBAZ2B | |
| Ethenzamide SCHEMBL25624 | 0.60 | MAPT (0.68) | MAPK1MEN1KMT2AGLALMNA | |
| Ethenzamide SCHEMBL27612766 | 0.60 | MAPT (0.68) | MAPK1MEN1KMT2AGLALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269295-B1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1991-06-26 | — | — | EP | disclosed |
| US-4877793-A | CARDIOVASCULAR DISORDERS | THE BOOTS COMPANY, PLC (GB) | 1989-10-31 | — | — | US | disclosed |