SCHEMBL9837458

SCHEMBL9837458

CC(C)(CCO)C(=O)O.[NaH]

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 1/20 0.46
ACACB O00763 1/20 0.45
ACACA Q13085 1/20 0.45
TSHR P16473 3/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
PPARA Q07869 5/20 0.35
TBXAS1 P24557 2/20 0.34
CYP1A2 P05177 2/20 0.33
CYP2C9 P11712 2/20 0.33
TTR P02766 1/20 0.33
CYP2C8 P10632 1/20 0.33
CHRM1 P11229 1/20 0.33
ADRA1A P35348 1/20 0.33
PPARG P37231 1/20 0.33
HTR2B P41595 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
SLCO1B3 Q9NPD5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL364285 0.97
SCHEMBL2151949 0.94 ACLY (0.46) ACLYACACBACACATSHRALDH1A1
Ammonia Solution, Strong SCHEMBL27774285 0.94 ACLY (0.46) ACLYACACBACACATSHRALDH1A1
Carbonotrithioic Acid SCHEMBL28987370 0.85 ACLY (0.41) ACLYACACBACACATSHRALDH1A1
SCHEMBL9837397 0.84 ACLY (0.54) ACLYACACBACACATSHRPPARA
SCHEMBL320771 0.82 ACLY (0.54) ACLYACACBACACATSHRALDH1A1
SCHEMBL5075315 0.81 ACLY (0.56) ACLYACACBACACATSHRPPARA
SCHEMBL8571217 0.79 ACLY (0.59) ACLYACACBACACATSHRPPARA
SCHEMBL127297 0.78
SCHEMBL2590354 0.78 ACLY (0.46) ACLYACACBACACATSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0211416-B1 NOVEL HMG-COA REDUCTASE INHIBITORS MERCK & CO. INC. (US) 1991-10-16 EP disclosed
US-4851436-A ANTICHOLESTEROL AND ANTILIPEMIC AGENTS MERCK & CO., INC. (US) 1989-07-25 US disclosed
US-4668699-A 6-(NAPHTHYLETHYL)TETRAHYDROPYRAN-2-ONES; ANTILIPEMIC, ANTICHOLESTEROL MERCK & CO., INC. (US) 1987-05-26 US disclosed
US-4665091-A 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ANTICHOLESTEROL MERCK & CO., INC. (US) 1987-05-12 US disclosed
EP-0211416-A2 Novel HMG-CoA reductase inhibitors MERCK & CO. INC. (US) 1987-02-25 EP disclosed