SCHEMBL9837397

SCHEMBL9837397

CC(C)(CCCO)C(=O)O.[NaH]

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 1/20 0.54
ACACB O00763 1/20 0.52
ACACA Q13085 1/20 0.52
CYP4F2 P78329 1/20 0.48
CYP4A11 Q02928 1/20 0.48
PPARA Q07869 7/20 0.41
TBXAS1 P24557 2/20 0.40
TTR P02766 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C8 P10632 1/20 0.39
CHRM1 P11229 1/20 0.39
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
ADRA1A P35348 1/20 0.39
PPARG P37231 1/20 0.39
HTR2B P41595 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
SLCO1B3 Q9NPD5 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CISD1 Q9NZ45 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5075315 0.97 ACLY (0.56) ACLYACACBACACACYP4F2CYP4A11
SCHEMBL8571217 0.95 ACLY (0.59) ACLYACACBACACACYP4F2CYP4A11
SCHEMBL6692276 0.93 ACLY (0.63) ACLYACACBACACACYP4F2CYP4A11
SCHEMBL28606082 0.93 ACLY (0.63) ACLYACACBACACACYP4F2CYP4A11
SCHEMBL28369873 0.93 ACLY (0.63) ACLYACACBACACACYP4F2CYP4A11
SCHEMBL6699125 0.93 ACLY (0.63) ACLYACACBACACACYP4F2CYP4A11
1,6-Hexanediol SCHEMBL11319932 0.85 ACLY (0.55) ACLYACACBACACACYP4F2CYP4A11
SCHEMBL9837458 0.84 ACLY (0.46) ACLYACACBACACACYP4F2CYP4A11
SCHEMBL2784372 0.84 ACLY (0.62) ACLYACACBACACAPPARATBXAS1
SCHEMBL7222208 0.84 ACLY (0.70) ACLYACACBACACACYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0211416-B1 NOVEL HMG-COA REDUCTASE INHIBITORS MERCK & CO. INC. (US) 1991-10-16 EP disclosed
US-4851436-A ANTICHOLESTEROL AND ANTILIPEMIC AGENTS MERCK & CO., INC. (US) 1989-07-25 US disclosed
US-4668699-A 6-(NAPHTHYLETHYL)TETRAHYDROPYRAN-2-ONES; ANTILIPEMIC, ANTICHOLESTEROL MERCK & CO., INC. (US) 1987-05-26 US disclosed
US-4665091-A 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ANTICHOLESTEROL MERCK & CO., INC. (US) 1987-05-12 US disclosed
EP-0211416-A2 Novel HMG-CoA reductase inhibitors MERCK & CO. INC. (US) 1987-02-25 EP disclosed