Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5705114 | 0.82 | CYP1A2 (0.52) | LMNAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL11440068 | 0.82 | F7 (0.47) | MTNR1AMTNR1BHTR2ANR4A2TSHR | |
| SCHEMBL9836327 | 0.75 | MTNR1A (0.78) | MTNR1AMTNR1BHTR2BHTR2AHTR2C | |
| SCHEMBL3214536 | 0.72 | MTNR1A (0.58) | MTNR1AMTNR1BHTR2BHTR2AHTR2C | |
| SCHEMBL7198422 | 0.70 | IDO1 (0.56) | MTNR1AMTNR1BHTR2BHTR2AHTR2C | |
| SCHEMBL2834218 | 0.70 | NR4A2 (0.75) | MTNR1AMTNR1BHTR2BNR4A2LMNA | |
| SCHEMBL5341311 | 0.70 | MTNR1A (0.67) | MTNR1AMTNR1BHTR2BHTR2AHTR2C | |
| SCHEMBL9026787 | 0.69 | HTR2B (0.54) | MTNR1AMTNR1BHTR2BHTR2AHTR2C | |
| SCHEMBL21255991 | 0.69 | MTNR1A (0.60) | MTNR1AMTNR1BHTR2BHTR2AHTR2C | |
| SCHEMBL24736529 | 0.69 | HTR2A (0.60) | MTNR1AMTNR1BHTR2BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224919-B1 | NEW THIAZOLE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4742057-A | Antiallergic thiazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |