Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 6/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MDH2 | P40926 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837468 | 0.82 | MTNR1A (0.56) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL5705170 | 0.79 | KDM4E (0.62) | CYP1A2CYP3A4CYP2C19LTA4HPLA2G2A | |
| SCHEMBL11440068 | 0.76 | F7 (0.47) | TRPM8SLC6A4HSD17B10 | |
| SCHEMBL6764594 | 0.76 | MAOB (0.61) | LTA4HPLA2G2ATRPM8MEN1KMT2A | |
| SCHEMBL6101206 | 0.73 | LTA4H (0.56) | LTA4HPLA2G2ATRPM8MEN1KMT2A | |
| SCHEMBL5363538 | 0.72 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2C19TRPM8KDM4E | |
| SCHEMBL26863407 | 0.72 | TRPM8 (0.56) | CYP1A2CYP3A4CYP2C19LTA4HPLA2G2A | |
| SCHEMBL5879349 | 0.72 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C19LTA4HPLA2G2A | |
| SCHEMBL852462 | 0.72 | TRPM8 (0.55) | CYP1A2CYP3A4CYP2C19LTA4HPLA2G2A | |
| SCHEMBL4573946 | 0.72 | TRPM8 (0.69) | LTA4HPLA2G2ATRPM8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691807-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES | Astellas Pharma Inc. (JP) | 2006-08-23 | — | — | EP | disclosed |
| US-20050245540-A1 | New methods | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-11-03 | — | — | US | disclosed |
| WO-2005056012-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES | ASTELLAS PHARMA INC. (JP) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245540-A1 | New methods | TGFB1, TGFBR1, TGFB2 | CYP1A2 1352/4885CYP3A4 2814/4885CYP2C19 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.