Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAT2A | P31153 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14836522 | 0.81 | PARP1 (0.41) | PARP1HPGDMAPTMEN1KMT2A | |
| SCHEMBL20074826 | 0.78 | MAPK14 (0.54) | ALDH1A1HTTKDRLMNASMN1; SMN2 | |
| SCHEMBL18073882 | 0.73 | PKM (0.37) | HPGDMAPTMEN1KMT2ARAB9A | |
| SCHEMBL33804 | 0.72 | MAPT (0.55) | HPGDMAPTMEN1KMT2ARAB9A | |
| SCHEMBL25434020 | 0.71 | TNK2 (0.37) | MAPTRAB9AHTTKDRNPC1 | |
| SCHEMBL25431774 | 0.71 | PDE7A (0.35) | HRH2HRH3ADORA2A | |
| SCHEMBL19926278 | 0.71 | MAPT (0.68) | HPGDMAPTMEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL6259439 | 0.71 | MAPT (0.53) | HPGDMAPTMEN1KMT2ARAB9A | |
| SCHEMBL4214390 | 0.71 | MAPT (0.58) | HPGDMAPTMEN1KMT2ARAB9A | |
| SCHEMBL19941724 | 0.70 | ALDH1A1 (0.44) | HPGDMAPTRAB9ANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0104522-B1 | NEW PYRAZOLO(3,4-B)PYRIDINE DERIVATIVES AND PROCESS FOR PRODUCING THEM | GRUPPO LEPETIT S.p.A. (IT) | 1991-05-29 | — | — | EP | disclosed |
| US-4612318-A | CNS-depressant and analgesic tricyclo-[pyrazolo-[3,4-6]-pyridine] derivatives and pharmaceutical compositions thereof | GRUPPO LEPETIT S.P.A. (IT) | 1986-09-16 | — | — | US | disclosed |
| EP-0104522-A2 | New pyrazolo(3,4-b)pyridine derivatives and process for producing them | GRUPPO LEPETIT S.p.A. (IT) | 1984-04-04 | — | — | EP | disclosed |