Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27030782 | 0.82 | ALDH1A1 (0.53) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL27736519 | 0.78 | HSD11B1 (0.61) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL2320664 | 0.77 | CA1 (0.56) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL1812296 | 0.75 | HSD11B1 (0.82) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL10185003 | 0.74 | HSD11B1 (0.57) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL3154297 | 0.74 | ALDH1A1 (0.52) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL1023276 | 0.74 | HSD11B1 (0.60) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL11453501 | 0.74 | HSD17B10 (0.52) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL677900 | 0.74 | HSD17B10 (0.52) | HSD11B1ALDH1A1CA1CA2CA5A | |
| SCHEMBL12208260 | 0.74 | HSD11B1 (0.56) | HSD11B1ALDH1A1CA1CA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4847295-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-07-11 | — | — | US | disclosed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | disclosed |