Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.43 |
| ▸ | TGM2 | P21980 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7178423 | 0.85 | EGFR (0.52) | EGFRTGM2HDAC3HDAC4HDAC1 | |
| SCHEMBL8686783 | 0.83 | CLCN2 (0.46) | TGM2CLCN2 | |
| SCHEMBL15093896 | 0.81 | HTT (0.53) | CLCN2DHFR | |
| SCHEMBL29580700 | 0.81 | HTT (0.53) | CLCN2DHFR | |
| SCHEMBL2018495 | 0.81 | CLCN2 (0.47) | CLCN2DHFRHDAC3HDAC4HDAC1 | |
| SCHEMBL3940043 | 0.80 | MAPK1 (0.50) | CLCN2 | |
| SCHEMBL9558740 | 0.80 | CACNA1C (0.51) | TGM2THRATHRBCLCN2 | |
| SCHEMBL1720103 | 0.78 | GAA (0.49) | CLCN2DHFRHDAC3HDAC4HDAC1 | |
| SCHEMBL21600596 | 0.78 | HPGD (0.48) | CLCN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28166963 | 0.77 | THRA (0.43) | EGFRFGFR4TGM2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071876-A | Antiinflammatory agent; antiallergen; skin disorders; asthma; enzyme inhibitors of 5-lipogenase | G. D. SEARLE & CO. (US) | 1991-12-10 | — | — | US | disclosed |