Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | KDM6B | O15054 | 2/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22763971 | 0.91 | KDM4E (0.69) | KDM4EGLAALDH1A1GAAPOLB | |
| SCHEMBL28588223 | 0.86 | KDM4E (0.56) | KDM4EGLAALDH1A1POLBATM | |
| SCHEMBL4897624 | 0.84 | KDM6B (0.69) | KDM4EALDH1A1POLBKMT2AMAPT | |
| SCHEMBL10363534 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1GAAPOLBKMT2A | |
| SCHEMBL28672732 | 0.83 | KDM4E (0.71) | KDM4EGLAALDH1A1GAAPOLB | |
| SCHEMBL27829693 | 0.83 | KDM4E (0.82) | KDM4EGLAALDH1A1GAAPOLB | |
| SCHEMBL5928710 | 0.82 | KDM4E (0.69) | KDM4EGLAALDH1A1GAAPOLB | |
| SCHEMBL28618228 | 0.82 | KDM4E (0.69) | KDM4EGLAALDH1A1GAAPOLB | |
| SCHEMBL27829710 | 0.82 | KDM4E (0.79) | KDM4EGLAALDH1A1GAAPOLB | |
| SCHEMBL22854454 | 0.81 | ALDH1A1 (0.68) | KDM4EGLAALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994493-A | Treatment of cerebral edema | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN (DE) | 1991-02-19 | — | — | US | disclosed |