Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19380526 | 0.83 | KDM4E (0.49) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A | |
| SCHEMBL8477532 | 0.76 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A | |
| SCHEMBL7809964 | 0.74 | KDM4E (0.53) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A | |
| SCHEMBL4714549 | 0.74 | KDM4E (0.53) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A | |
| SCHEMBL23112391 | 0.73 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A | |
| SCHEMBL19380525 | 0.73 | TSHR (0.42) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A | |
| SCHEMBL8709408 | 0.73 | HTR2A (0.45) | KDM4EHSD17B10ALDH1A1LMNACTNNB1 | |
| Hydrazine SCHEMBL14688080 | 0.72 | KDM4E (0.43) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A | |
| SCHEMBL77894 | 0.71 | KDM4E (0.44) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A | |
| SCHEMBL4714664 | 0.71 | KDM4E (0.58) | KDM4EHSD17B10ALDH1A1LMNAMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008452-A | Antidepressants, sedatives and anticonvulsants | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-04-16 | — | — | US | disclosed |
| US-4235931-A | ANTIDEPRESSANTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-11-25 | — | — | US | disclosed |
| US-4192818-A | ANTIDEPRESSANTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-03-11 | — | — | US | disclosed |