Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20561907 | 0.88 | AOC3 (0.46) | HTR2AHTR2CHTR2BKDM4EATM | |
| SCHEMBL12461810 | 0.82 | CTNNB1 (0.43) | KDM4ECTNNB1WNT3ALMNAALDH1A1 | |
| SCHEMBL20562552 | 0.80 | HTR2C (0.51) | HTR2AHTR2CHTR2BKDM4EATM | |
| SCHEMBL8704567 | 0.76 | MTNR1A (0.57) | CTNNB1WNT3ALMNA | |
| SCHEMBL16703478 | 0.75 | LMNA (0.44) | KDM4ECTNNB1WNT3ALMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL20563084 | 0.75 | HTR2A (0.43) | HTR2AHTR2CHTR2BKDM4EATM | |
| Hydrochloric Acid SCHEMBL20563956 | 0.74 | HTR2A (0.42) | HTR2AHTR2CHTR2BKDM4ELMNA | |
| SCHEMBL12998493 | 0.73 | ALDH1A1 (0.49) | KDM4ECTNNB1WNT3ALMNAALDH1A1 | |
| SCHEMBL20562703 | 0.73 | AOC3 (0.64) | HTR2AHTR2CHTR2BALDH1A1TAAR1 | |
| SCHEMBL9838523 | 0.73 | KDM4E (0.46) | KDM4ECTNNB1WNT3ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708020-A | FOR TREATING SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-13 | — | — | US | disclosed |
| US-5604261-A | HAVING HYDROXYL/ALKOXYL GROUP ORTHO TO AMIDE GROUP ON PHENYL RING; HIGH MELATONIN RECEPTOR AFFINITY | ADIR ET COMPAGNIE (FR) | 1997-02-18 | — | — | US | disclosed |
| US-5554642-A | USE TO TREAT MAMMALS AFFLICTED WITH SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1996-09-10 | — | — | US | disclosed |
| EP-0591057-B1 | Arylalkyl(thio)amides with melatonine receptor selectivity and process for their preparation | ADIR (FR) | 1996-07-10 | — | — | EP | disclosed |
| US-5464872-A | Sleep disorders | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0591057-A1 | Arylalkyl(thio)amides with melatonine receptor selectivity and process for their preparation | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |