Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427488 | 0.86 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL6341931 | 0.86 | AOC3 (0.43) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL17424960 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL668947 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL4714549 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL20563025 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL17424932 | 0.81 | BAZ2B (0.49) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL23112391 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL8477532 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL668435 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1HSD17B10HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741709-B1 | AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS | ALLERGAN SALES INC (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-0741709-A1 | AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS | Allergan (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019968-A1 | AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS | ALLERGAN (US) | 1995-07-27 | — | — | WO | disclosed |