Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838573 | 0.85 | HSP90AB1 (0.43) | TAAR1HSP90AB1RAB9ANPC1CYP1A2 | |
| SCHEMBL9837140 | 0.83 | HTT (0.49) | TAAR1MEN1KMT2A | |
| SCHEMBL21356997 | 0.83 | TAAR1 (0.56) | TAAR1HTR2AHTR1DCYP1A2CYP2A6 | |
| SCHEMBL9838470 | 0.83 | TAAR1 (0.56) | TAAR1HTR2AHTR1DRAB9ANPC1 | |
| SCHEMBL17749060 | 0.77 | HSP90AB1 (0.42) | HSP90AB1RAB9ANPC1POLBMEN1 | |
| SCHEMBL15947157 | 0.76 | TAAR1 (0.67) | TAAR1HTR2AHTR1DCYP1A2CYP2A6 | |
| SCHEMBL9838510 | 0.76 | TAAR1 (0.56) | TAAR1HTR2AHTR1DCYP1A2CYP2A6 | |
| SCHEMBL27520516 | 0.76 | TAAR1 (0.56) | TAAR1HTR2AHTR1DCYP1A2CYP2A6 | |
| SCHEMBL30494600 | 0.75 | HSP90AB1 (0.47) | HSP90AB1RAB9ANPC1POLBMEN1 | |
| SCHEMBL9043077 | 0.75 | HSP90AB1 (0.47) | HSP90AB1RAB9ANPC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008452-A | Antidepressants, sedatives and anticonvulsants | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-04-16 | — | — | US | disclosed |
| US-4235931-A | ANTIDEPRESSANTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-11-25 | — | — | US | disclosed |
| US-4192818-A | ANTIDEPRESSANTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-03-11 | — | — | US | disclosed |