Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838536 | 0.85 | TAAR1 (0.53) | HSP90AB1RAB9ANPC1POLBMEN1 | |
| SCHEMBL29140046 | 0.82 | CSNK2A1 (0.48) | MEN1KMT2AALDH1A1SMN1; SMN2CSNK2A1 | |
| SCHEMBL4976602 | 0.81 | MAPK8 (0.39) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL17749060 | 0.78 | HSP90AB1 (0.42) | HSP90AB1RAB9ANPC1POLBMEN1 | |
| SCHEMBL581464 | 0.76 | HSD11B1 (0.54) | HSP90AB1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11501019 | 0.74 | STAT3 (0.41) | HSP90AB1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9639259 | 0.74 | HSP90AB1 (0.69) | HSP90AB1RAB9ANPC1POLBMEN1 | |
| SCHEMBL9043077 | 0.73 | HSP90AB1 (0.47) | HSP90AB1RAB9ANPC1POLBMEN1 | |
| SCHEMBL22614748 | 0.73 | HSP90AB1 (0.47) | HSP90AB1RAB9ANPC1POLBMEN1 | |
| SCHEMBL30494600 | 0.73 | HSP90AB1 (0.47) | HSP90AB1RAB9ANPC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008452-A | Antidepressants, sedatives and anticonvulsants | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-04-16 | — | — | US | disclosed |
| US-4235931-A | ANTIDEPRESSANTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-11-25 | — | — | US | disclosed |
| US-4192818-A | ANTIDEPRESSANTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-03-11 | — | — | US | disclosed |