Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838505 | 0.87 | HTT (0.50) | HTTGAATDP1L3MBTL1MAPT | |
| SCHEMBL9838536 | 0.83 | TAAR1 (0.53) | TAAR1MEN1KMT2A | |
| SCHEMBL11484974 | 0.83 | TAAR1 (0.46) | HTTTAAR1GAATDP1L3MBTL1 | |
| SCHEMBL11484976 | 0.82 | HTT (0.46) | HTTMAPTHSD17B3MEN1KMT2A | |
| Ethylenediamine SCHEMBL11233243 | 0.80 | HTT (0.64) | HTTGAATDP1L3MBTL1MAPT | |
| SCHEMBL28382016 | 0.79 | HTT (0.57) | HTTGAATDP1L3MBTL1MAPT | |
| SCHEMBL21356997 | 0.77 | TAAR1 (0.56) | TAAR1MEN1KMT2A | |
| SCHEMBL9838470 | 0.77 | TAAR1 (0.56) | HTTTAAR1L3MBTL1MAPTMEN1 | |
| SCHEMBL8674913 | 0.76 | HTT (0.71) | HTTGAATDP1L3MBTL1MAPT | |
| SCHEMBL27712176 | 0.76 | HTT (0.50) | HTTGAATDP1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008452-A | Antidepressants, sedatives and anticonvulsants | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-04-16 | — | — | US | disclosed |
| US-4235931-A | ANTIDEPRESSANTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-11-25 | — | — | US | disclosed |
| US-4192818-A | ANTIDEPRESSANTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-03-11 | — | — | US | disclosed |