Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.55 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838718 | 0.93 | MEN1 (0.68) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL8554461 | 0.91 | KCNH2 (0.69) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL9837304 | 0.90 | KCNH2 (0.69) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL9839457 | 0.87 | ALDH1A1 (0.50) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL9435467 | 0.86 | MEN1 (0.79) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL8558544 | 0.85 | KCNH2 (0.66) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL9688214 | 0.84 | POLB (0.69) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL8555217 | 0.83 | MEN1 (0.68) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL8558517 | 0.83 | KCNH2 (0.70) | KCNH2HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL8433684 | 0.83 | ALDH1A1 (0.77) | KCNH2HRH3MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226961-B1 | 5-AMINO AND 5-HYDROXY-6,8-DIFLUOROQUINOLONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | claimed |
| US-4977154-A | 7-PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1990-12-11 | — | — | US | claimed |
| CN-86108942-A | Amino and the 5-hydroxyl-6 as the 5-of antimicrobial drug, 8-two fluoroquinolones | — | 1987-11-04 | — | — | CN | claimed |
| EP-0226961-A1 | 5-Amino and 5-hydroxy-6,8-difluoroquinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1987-07-01 | — | — | EP | claimed |
| EP-0226961-B1 | 5-AMINO AND 5-HYDROXY-6,8-DIFLUOROQUINOLONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4977154-A | 7-PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| CN-86108942-A | Amino and the 5-hydroxyl-6 as the 5-of antimicrobial drug, 8-two fluoroquinolones | — | 1987-11-04 | — | — | CN | disclosed |
| EP-0226961-A1 | 5-Amino and 5-hydroxy-6,8-difluoroquinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1987-07-01 | — | — | EP | disclosed |