Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 3/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877382 | 0.91 | GSK3B (0.53) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL7576011 | 0.90 | GSK3B (0.66) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL9688639 | 0.88 | GSK3B (0.60) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL9376888 | 0.86 | GSK3B (0.53) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL7577816 | 0.85 | ADRB2 (0.51) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL1344780 | 0.84 | MEN1 (0.68) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL10545442 | 0.83 | MEN1 (0.52) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL9757352 | 0.82 | GSK3B (0.58) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL5868648 | 0.82 | GSK3B (0.60) | GSK3BMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL12674057 | 0.81 | GSK3B (0.63) | GSK3BMEN1KMT2ATOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226961-B1 | 5-AMINO AND 5-HYDROXY-6,8-DIFLUOROQUINOLONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| EP-0221463-A2 | Quinoline derivatives and processes for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-05-13 | — | — | EP | disclosed |